Aspartame Observed Side Effects

ASPARTAME OBSERVED SIDE EFFECTS 6

AspartameObserved Side Effects

TheSide Effects That Have Been Seen Of Aspartame

Aspartameis a synthetic chemical that is made up of methyl eater and two aminoacids aspartic acid and phenylalamine. The former is perceived to bea severe poison. The FDA approved the use of Aspartame in form of alow nutritive sweetener that could be used in solid foods in 1981 andin soft drinks in 1983. This approval was resisted by most senior FDAofficials on grounds that the animal studies had warning findingsespecially the prevalence of brain tumors in rats. It is believedthat the experimental data was flawed and there were also noextensive trails on humans for premarketing purposes (Fernstrom,2013).

Thereare various physiologic and even metabolic disturbances which explainthese clinical complications. The damage to the retina or the eye’soptic nerves is purely due to exposure to methyl alcohol. Comparedto animals’ human beings are not capable of metabolizing it. Thebrain tends to have high concentrations of aspartic acid coupled withphenylalamine after a person consumes aspartame this however, doesnot occur in the ordinary partake of proteins that have standardizedamino acid levels (Freeman, 1990).

Aspartamealso has the side effect of altering the functions of critical aminoacids that are derived from neurotransmitters particularly inindividuals that are obese and after a person takes carbohydrates. There are vague signs after the consumption of Aspartame whoseoutcome is the critical anorexia or rapid food consumption. TheAspartame products causative role has been exhibited by the timelyimprovement of symptoms after their consumption is halted. Thesesymptoms include serious gastrointestinal reactions, grand mailseizures, rashes, headache and itching (Stegink,2010).

Parkinson’sdisease is amongst a cohort of motor system disorders that realizesthe loss of dopamine generating brain cells. There is considerableevidence suggesting that Parkinson’s disease is a disorder whosecause is linked to Aspartame excitotoxicity.The combined reactionsof phenylalamine and aspartate in the Aspartame demolish the braincells that pertain to this disease. The excitotoxins make braincells to produce substantial amounts of free radicals (Freeman,1990).

Dr.Hyman Jacob Roberts is the director of a medical research institutelocated in Palm Beach USA. He has published more than 17 texts andover 200 letters and articles on neurological problems, diagnosticdifficulties and metabolic challenges that stem from Aspartamepoisoning. According to his Parkinson’s disease findings theretends to be a modification in the concentrations of dopamine andserotonin found in the brain (Stegink,2010).

Thephenylalamine enzyme converts it to tyrosine which is converted todihydroxyphenylalanine (DOPA) this is then converted to dopamine.According to Dr. Hyman Jacob Roberts whenever the cortical glutamatecells get overexcited by aspartate it generates Parkinsonism which isa nervous disorder that resembles Parkinson’s disease. This ismarked by impaired motor control, muscular rigidity and tremor as aresult of exposure to toxic chemicals.

Thecortical glutamate cells then get connected to the nigrostriatalcells located deeper in the brain. Aspartic acid has been proven tobe the cause of this damage in the basal ganglia area where thedegeneration of Parkinson’s disease takes place. Aspartame’smolecular structure realizes an aspartic acid damage that is 5000times compared to that of free aspartic acid. The reduction in thequantity of dopamine a neurotransmitter that enhances the normalfunctioning of the brain results to Parkinson’s disease (Yokogoshi,2012).

Ithad been hypothesized in the recent past that aspartame given its Plccontent could impact human behavior, through physiological andcognitive functions. Headaches were found in most studies to be themost reported mild symptoms after one consumed aspartame. However,there has been no treatment associated impact in most tests whichemployed aspartame doses of up to 60 mg per kg.

Consequently,Patients that are seen to have the following symptoms normal pressurehydrocephalus, seizures, carpal tunnel syndrome, headache,depression, a characteristic eye pain and the meniere syndrome shouldbe queried on their use of aspartame. In addition all patients thathave metabolic, unresolved neurologic, endocrine, psychological,gastrointestinal, allergic and dermatologic challenges must test ontheir take of aspartate.

Thereis also a need to defer cataract surgery to heavy aspartame users toassess for impulsive developments upon abstaining. Multiple sclerosisdiagnosis should be differed until the situation is observed for somemonths for people who consume aspartame. Pregnant women should notput the fetus at risk through aspartame consumption. Bowel, visualand neurologic diabetic challenges should not be attributed toexisting neuropathy or retinal problems until the situation isassessed on aspartame self-discipline (Wurtman,2011).

Conclusion

Aspartameis a synthetic chemical that is made up of methyl eater and two aminoacids aspartic acid and phenylalamine. There are various physiologicand even metabolic disturbances which explain these clinicalcomplications. Aspartame also has the side effect of altering thefunctions of critical amino acids that are derived fromneurotransmitters particularly in individuals that are obese andafter a person takes carbohydrates. Consequently, Patients that areseen to have the following symptoms normal pressure hydrocephalus,seizures, carpal tunnel syndrome, headache, depression, acharacteristic eye pain and the meniere syndrome should be queried ontheir use of aspartame.

References

Fernstrom,J. D., Fernstrom, M. H. &amp Gillis, M. A.(2013)Acute effects of aspartame on largeneutralamino acids and monoamines in rat brain.LifeSci. 32, 1651-1658

FreemanG, Sobotka T and Hattan D (1990). Acute effects of aspartame onconcentrations of brain amines and their metabolites in selectedbrain regions of Fischer-344 and Sprague-Dawley rats. Drug and ChemTox 13:113-133.

Stegink,L. D, Filer, L. J., Jr. &amp Baker, G. L. (2010) Effect of aspartameand aspartate loading upon plasma and erythrocyte free amino acidlevels in normal adult volunteers. J. Nutr. 107, 1839-1845.

Wurtman,R. J. (2011) Neurochemical changes following high-dose aspartame withdietary car bohydrate. N. Engl. J. Med. 309, 429-430.

Yokogoshi,H., Roberts, C. H., Caballero, B. &amp Wurtman, R. J. (2012) Effectsof aspartame and glucose administration on brain and plasma levels oflarge neutral amino acids and brain 5-hydroxyindoles. Am. J. Clin.Nutr. 40, 1-7.