Patho Discussion – Week 9 Diabetes

[PathoDiscussion – Week 9] Diabetes

Pathophysiologyof diabetes insipidus

There’stotal or partial inability in the victims of this condition to holdurine for quite a long time. The ADH activities are not sufficient,and this leads to excreting diluted urine in large volumes resultingto increase in plasma osmolality (Hammer and McPhee, 2014). If thecondition worsens, the victim may experience extreme thirst and afeeling to take cold drinks.

Pathophysiologyof diabetes mellitus

Thetype 1A is characterized by beta cells’ destruction of thepancreas this result to the deficiency of insulin. Type 2 leads to asecretory defect of insulin.

Differencesand similarities between the resulting hormonal regulationsalterations


Thechanges of hormones in both conditions result to frequent urinationand a prolonged feeling of thirsty.


TheDiabetes insipidus hormonal secreting mechanism malfunctions whereasin Mellitus the insulin hormone is not secreted in plenty.Reabsorption of water in insipidus is not possible by the kidneys ofthe victim whereas in Mellitus there’s excessive amount of sugar inthe urine.

Impactof gender and age in diagnosis and prescription of diabetes Mellitusand Insipidus


Insipiduscan either be central or nephrogenic. The central insipidus occurs atany age after infancy whereas conditions of inherited nephrogenicinspidus appear a short period after birth.

Mellitustype1A is more pronounced in ages of 11-13 years but for girls it maybe slightly early than this. Type 2 is common in the age of 40 yearsand above (Huether and McCance, 2014)


Theeffect of central insipidus in both male and female is the same. Theinherited nephrogenic is more pronounced on males because it isX-linked whereas females may only be carriers.

Mellitustype 1A affects both genders equally the same case with type 2.


Golan,E. D. (2008). Principlesof Pharmacology. The Pathophysiologic Basis of Drug Therapy.Lippincott Williams &amp Wilkins.

Hammer,D.G &amp McPhee, J.S. (2014). Pathophysiologyof Disease. An Introduction to Clinical Medicine.McGraw-Hill Education-Europe.

Huether,E.S &amp McCance, L.K. (2013). UnderstandingPathophysiology.Elsevier Health Sciences.

Siegenthaler,W. (2007).Differential Diagnosis in Internal Medicine from Symptom toDiagnosis.Thieme Publishers.